4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin

Base Information

Chemical Name:4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin
CAS No.:119368-32-0
Molecular Formula:C₂₇H₂₆N₄O₅
Molecular Weight:486.527
Hs Code.:

Synonyms:4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin

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Chemical Property of 4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin

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Technology Process of 4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin

There total 4 articles about 4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 119368-17-1
C₂₇H₂₄N₆O₅

: 119368-32-0
4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 2327.2 Torr; Ambient temperature;
DOI:10.1021/jm00125a004

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 119368-32-0
4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) CH₃CN, r.t., 1 h, 2) CH₃CN, r.t., 2 h

2: 91 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 2327.2 Torr / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00125a004

Reference yield:

: 29274-28-0
4-Chloro-1H-pyrazolo<3,4-b>pyridine

: 119368-32-0
4-Amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-pyrazolo<3,4-b>pyridin

Guidance literature:: Multi-step reaction with 3 steps

1: 1) TFA, 2) NaN₃ / 1) r.t., 1 h, 2) DMF, 110 deg C, 2 h

2: 1) NaH / 1) CH₃CN, r.t., 1 h, 2) CH₃CN, r.t., 2 h

3: 91 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 2327.2 Torr / Ambient temperature

With sodium azide; hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00125a004