(2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid

Base Information

• Chemical Name: (2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid
• CAS No.: 170964-45-1
• Molecular Formula: C₂₇H₄₄F₃NO₆S
• Molecular Weight: 567.711

Synonyms:(2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid

Chemical Property of (2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid

Chemical Property:

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Technology Process of (2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid

There total 5 articles about (2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → (2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid (170964-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 3 h / Ambient temperature

2: 1 N NaOH / methanol / 48 h / Ambient temperature

With pyridine; sodium hydroxide; In methanol;

DOI:10.7164/antibiotics.48.929

Reference yield:

(2R,3R,3'R)-3-hydroxy-2-(3'-hydroxy-15'-methylhexadecanoylamino)-15-methyl-hexadecan-1-sulfonic acid (169217-35-0) → (2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid (170964-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 5percent HCl / 90 °C

2: pyridine / 3 h / Ambient temperature

3: 1 N NaOH / methanol / 48 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; In methanol;

DOI:10.7164/antibiotics.48.929

Reference yield:

(2R,3R)-3-Hydroxy-2-(13'-methyltetradecanoylamino)-15-methylhexadecanesulfonic acid (170242-21-4) → (2R,3R)-3-Hydroxy-15-methyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-hexadecane-1-sulfonic acid (170964-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 5percent HCl / Heating

2: pyridine / 3 h / Ambient temperature

3: 1 N NaOH / methanol / 48 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; In methanol;

DOI:10.7164/antibiotics.48.929

upstream raw materials:

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-13-methyl-1-[(R)-2-sulfo-1-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-ethyl]-tetradecyl ester

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(2R,3R,3'R)-3-hydroxy-2-(3'-hydroxy-15'-methylhexadecanoylamino)-15-methyl-hexadecan-1-sulfonic acid

(2R,3R)-2-amino-3-hydroxy-15-methyl-hexadecan-1-sulfonic acid

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