5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid

Base Information

Chemical Name:5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid
CAS No.:869997-37-5
Molecular Formula:C₂₄H₃₀N₂O₃
Molecular Weight:394.514
Hs Code.:

5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1<i>H</i>-imidazole-4-carboxylic acid

Synonyms:5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid

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Chemical Property of 5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid

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Technology Process of 5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid

There total 5 articles about 5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869997-63-7
5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid benzyl ester

: 869997-37-5
5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0490686

Reference yield:

: (adamantan-1-yloxy)-acetyl chloride

: 869997-37-5
5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 105.6 g / N,O-trimethylsilylacetamide / benzene / 16 h / 20 °C

2: 80 percent / OXONE; (C₄H₉)4NBr / CH₂Cl₂ / 48 h / 20 °C

3: NH₄OAc; AcOH / 70 °C

4: H₂ / Pd/C / tetrahydrofuran; methanol

With Oxone; N,O-bis-(trimethylsilyl)-acetamide; ammonium acetate; tetrabutylammomium bromide; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jm0490686

Reference yield:

: 269071-40-1
4-(adamantan-1-yloxy)-2,3-dioxobutyric acid benzyl ester

: 869997-37-5
5-(adamantan-1-yloxymethyl)-2-(2,4,6-trimethyl-phenyl)-1H-imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NH₄OAc; AcOH / 70 °C

2: H₂ / Pd/C / tetrahydrofuran; methanol

With ammonium acetate; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0490686