2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

Base Information

Chemical Name:2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid
CAS No.:1458656-93-3
Molecular Formula:C₃₁H₃₂FNO₇S
Molecular Weight:581.662
Hs Code.:

Synonyms:2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

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Chemical Property of 2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

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Technology Process of 2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

There total 8 articles about 2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1458653-56-9
methyl 2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

: 1458656-93-3
2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

Guidance literature:: With isopropyl alcohol; sodium hydroxide; In water; at 20 ℃; for 12h;

Reference yield:

: 1458652-58-8
methyl 2-((S)-6-((R)-4-bromo-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

: 1458656-93-3
2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere; Sealed tube

2: potassium phosphate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 1 h / 120 °C / Inert atmosphere; Sealed tube

3: sodium hydroxide; isopropyl alcohol / water / 12 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; palladium diacetate; isopropyl alcohol; sodium hydroxide; In 1,4-dioxane; water; toluene;

Reference yield:

: 1003048-72-3
4-bromo-7-fluoro-2,3-dihydro-1H-inden-1-one

: 1458656-93-3
2-((S)-6-((R)-4-(2,6-dimethyl-4-(1-(methylsulfonyl)-azetidin-3-yloxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: formic acid; triethylamine; chloro([(S,2S)-(?)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido)(mesitylene)ruthenium (II) / dichloromethane / 16 h / 20 °C / Cooling with ice; Inert atmosphere

2: di-tert-butyl-diazodicarboxylate; tributylphosphine / tetrahydrofuran / 0.5 h / -10 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere; Sealed tube

4: potassium phosphate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 1 h / 120 °C / Inert atmosphere; Sealed tube

5: sodium hydroxide; isopropyl alcohol / water / 12 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; chloro([(S,2S)-(?)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido)(mesitylene)ruthenium (II); formic acid; tributylphosphine; di-tert-butyl-diazodicarboxylate; potassium acetate; palladium diacetate; triethylamine; isopropyl alcohol; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;