(1R,2S,8aS)-5,5,8a-trimethyl-1-(2-hydroxyethyl)-2-hydroxy-trans-perhydronaphthalene

Base Information

Chemical Name:(1R,2S,8aS)-5,5,8a-trimethyl-1-(2-hydroxyethyl)-2-hydroxy-trans-perhydronaphthalene
CAS No.:60113-31-7
Molecular Formula:C₁₅H₂₈O₂
Molecular Weight:240.386
Hs Code.:

Synonyms:(1R,2S,8aS)-5,5,8a-trimethyl-1-(2-hydroxyethyl)-2-hydroxy-trans-perhydronaphthalene

Suppliers and Price of (1R,2S,8aS)-5,5,8a-trimethyl-1-(2-hydroxyethyl)-2-hydroxy-trans-perhydronaphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,8aS)-5,5,8a-trimethyl-1-(2-hydroxyethyl)-2-hydroxy-trans-perhydronaphthalene

Chemical Property:

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Technology Process of (1R,2S,8aS)-5,5,8a-trimethyl-1-(2-hydroxyethyl)-2-hydroxy-trans-perhydronaphthalene

There total 2 articles about (1R,2S,8aS)-5,5,8a-trimethyl-1-(2-hydroxyethyl)-2-hydroxy-trans-perhydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 596-85-0
manool

: 60113-31-7
(1R,2S,8aS)-5,5,8a-trimethyl-1-(2-hydroxyethyl)-2-hydroxy-trans-perhydronaphthalene

Guidance literature:: Multistep reaction; (i) POCl₃, Py, (ii) O₃, EtOH, hexane, (iii) NaBH₄, EtOH;
DOI:10.1002/hlca.19760590418

Reference yield:

: 596-85-0,1438-62-6,29461-42-5,41357-91-9,106631-38-3
manool

: 60113-31-7,82053-46-1,86023-47-4,86784-39-6
(8RS)-13,14,15,16,17-pentanorlabdane-8,12-diol

Guidance literature:: Multi-step reaction with 9 steps

1: 5 g / t-butyl hydroperoxide, vanadyl acetylacetonate / benzene

2: 4.7 g / LiAlH₄ / diethyl ether / 1 h / Heating

3: 3.5 g / sodium periodate / H₂O; methanol / Ambient temperature

4: 3.2 g / sodium hypobromite / dioxane

5: 0.57 g / LDA, diperoxo(oxohexamethylphosphoramido)molybdenum(VI) / tetrahydrofuran; hexane / 2 h / -5 °C

6: 0.6 g / LiAlH₄ / diethyl ether / 1 h / Heating

7: 0.1 g / sodium periodate / H₂O; methanol / Ambient temperature

8: 0.09 g / LiAlH₄ / diethyl ether / 0.5 h / Heating

9: 1.) O₃, 2.) LiAlH₄ / 1.) methanol, -78 deg C, 2.) ether, reflux, 0.5 h

With tert.-butylhydroperoxide; sodium periodate; lithium aluminium tetrahydride; sodium hypobromide; diperoxo(oxohexamethylphosphoramido)molybdenum(VI); vanadyl acetylacetonate; ozone; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; water; benzene;
DOI:10.1071/CH9880711