5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione

Base Information

Chemical Name:5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione
CAS No.:174724-41-5
Molecular Formula:C₂₄H₂₇NO₄S
Molecular Weight:425.549
Hs Code.:

Synonyms:5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione

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Chemical Property of 5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione

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Technology Process of 5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione

There total 6 articles about 5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1375483-16-1
5-[1-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-phenyl]-meth-(Z)-ylidene]-thiazolidine-2,4-dione

: 174724-41-5
5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; at 20 ℃; for 20h; under 3620.13 Torr;
DOI:10.1016/j.ejmech.2012.02.044

Reference yield:

: 540778-64-1
2,5,7,8-tetramethyl-6-trifluoromethanesulfonyloxy-chroman-2-carboxylic acid ethyl ester

: 174724-41-5
5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen; triethylamine / tetrahydrofuran; methanol / 20 h / 20 °C / 3620.13 Torr

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere

3: pyridine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere

5: piperidine / ethanol / 24 h / Inert atmosphere; Reflux

6: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr

With piperidine; pyridine; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.02.044

Reference yield:

: 1375483-10-5
2,5,7,8-tetramethyl-chroman-2-carboxylic acid ethyl ester

: 174724-41-5
5-[4-(2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere

2: pyridine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere

4: piperidine / ethanol / 24 h / Inert atmosphere; Reflux

5: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr

With piperidine; pyridine; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.02.044