Pilocarpine nitrate

Base Information

• Chemical Name: Pilocarpine nitrate
• CAS No.: 148-72-1
• Molecular Formula: C11H16N2O2^.HNO3
• Molecular Weight: 271.273
• Hs Code.: 2939800000
• European Community (EC) Number: 205-723-7
• NSC Number: 757282
• UNII: M20T465H6J
• DSSTox Substance ID: DTXSID80883277
• Wikidata: Q27283365
• NCI Thesaurus Code: C91038
• ChEMBL ID: CHEMBL1213136
• Mol file: 148-72-1.mol

Synonyms:Hydrochloride, Pilocarpine;Isopilocarpine;Isoptocarpine;Nitrate, Pilocarpine;Ocusert;Pilocarpine;Pilocarpine Hydrochloride;Pilocarpine Mononitrate, (3S-cis)-Isomer;Pilocarpine Nitrate;Pilocarpine, Monohydrochloride, (3S-cis)-Isomer;Salagen

Chemical Property of Pilocarpine nitrate

Chemical Property:

• Vapor Pressure: 1.16E-11mmHg at 25°C
• Melting Point: 173,5-174°C
• Refractive Index: 81 ° (C=2, H2O)
• Boiling Point: 520.5 °C at 760 mmHg
• Flash Point: 268.6 °C
• PSA: 110.17000
• LogP: 1.33730
• Storage Temp.: 2-8°C
• Solubility.: H2O: 0.1 g/mL, clear, very faintly yellow
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 271.11682065
• Heavy Atom Count: 19
• Complexity: 270

Purity/Quality:

Pilocarpine Nitrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,T+
• Hazard Codes: Xn,T+
• Statements: 22-26/28
• Safety Statements: 1-25-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1C(COC1=O)CC2=CN=CN2C.[N+](=O)(O)[O-]
• Isomeric SMILES: CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C.[N+](=O)(O)[O-]
• Recent EU Clinical Trials: Evaluation of inflammatory markers in patients on topical anti-glaucoma drop therapy; a comparative trial of preserved and non-preserved primary medical treatment (eye drops) in patients with glaucoma and ocular hypertension – a pilot study.
• Uses: antiglaucoma agent, miotic Antiglaucoma drug;Cholinergic Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Technology Process of Pilocarpine nitrate

There total 1 articles about Pilocarpine nitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-ethylidene-4-[(1-methylimidazol-5-yl)methyl]tetrahydrofuran-2-one (1192231-13-2) → pilocarpine nitrate (148-72-1)

Guidance literature:

(R)-3-ethylidene-4-[(1-methylimidazol-5-yl)methyl]tetrahydrofuran-2-one; With platinum(IV) oxide; hydrogen; In methanol; at 20 ℃; for 24h;

With nitric acid; In ethanol; water; at 0 ℃; Cooling;

DOI:10.1016/j.tet.2009.07.010

upstream raw materials:

(R)-3-ethylidene-4-[(1-methylimidazol-5-yl)methyl]tetrahydrofuran-2-one

Refernces