(R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-(m-tolyl)pyrrolidin-3-yl)-2-phenylacetate

Base Information

• Chemical Name: (R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-(m-tolyl)pyrrolidin-3-yl)-2-phenylacetate
• CAS No.: 1312945-54-2
• Molecular Formula: C₂₂H₂₀N₂O₄
• Molecular Weight: 376.412
• Mol file: 1312945-54-2.mol

Synonyms:(R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-(m-tolyl)pyrrolidin-3-yl)-2-phenylacetate

Chemical Property of (R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-(m-tolyl)pyrrolidin-3-yl)-2-phenylacetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-(m-tolyl)pyrrolidin-3-yl)-2-phenylacetate

There total 1 articles about (R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-(m-tolyl)pyrrolidin-3-yl)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-methylphenyl)-1H-pyrrole-2,5-dione (20299-79-0) + ethyl phenylcyanoacetate (4553-07-5) → (S)-ethyl 2-cyano-2-((R)-2,5-dioxo-1-(m-tolyl)pyrrolidin-3-yl)-2-phenylacetate + (R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-(m-tolyl)pyrrolidin-3-yl)-2-phenylacetate (1312945-54-2) + C22H20N2O4

Guidance literature:

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 ℃; for 7h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2011.04.009

upstream raw materials:

1-(3-methylphenyl)-1H-pyrrole-2,5-dione

ethyl phenylcyanoacetate