(+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one

Base Information

• Chemical Name: (+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one
• CAS No.: 145887-41-8
• Molecular Formula: C₁₂H₁₃N₅O₂
• Molecular Weight: 259.268
• Mol file: 145887-41-8.mol

Synonyms:(+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one

Chemical Property of (+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one

There total 4 articles about (+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(+/-)-4-cyanomethyl-1-(4-methoxyphenyl)azetidin-2-one (145887-50-9) → (+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one (145887-41-8)

Guidance literature:

With aluminium trichloride; sodium azide; In tetrahydrofuran; for 24h; Heating;

DOI:10.1039/P19920003061

Reference yield:

4-hydroxymethyl-1-(4-methoxyphenyl)-2-azetidinone (145985-24-6) → (+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one (145887-41-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / pyridine / 3 h / Ambient temperature

2: 89 percent / sodium iodide / acetone / 12 h / Heating

3: 62 percent / dimethylformamide / 6 h / Ambient temperature

4: 82 percent / sodium azide, AlCl₃ / tetrahydrofuran / 24 h / Heating

With pyridine; aluminium trichloride; sodium azide; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

DOI:10.1039/P19920003061

Reference yield:

rac-4-iodomethyl-1-(4-methoxyphenyl)-4-oxoazetidin-2-one (145887-49-6) → (+/-)-1-(4-methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one (145887-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / dimethylformamide / 6 h / Ambient temperature

2: 82 percent / sodium azide, AlCl₃ / tetrahydrofuran / 24 h / Heating

With aluminium trichloride; sodium azide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/P19920003061

upstream raw materials:

(+/-)-4-cyanomethyl-1-(4-methoxyphenyl)azetidin-2-one

4-hydroxymethyl-1-(4-methoxyphenyl)-2-azetidinone

rac-4-iodomethyl-1-(4-methoxyphenyl)-4-oxoazetidin-2-one

(+/-)-4-(methylsulfonyloxymethyl)-1-(4-methoxyphenyl)azetidin-2-one

Downstream raw materials:

4-(2-diphenylmethyltetrazol-5-ylmethyl)azetidin-2-one

4-(1-benzyltetrazol-5-ylmethyl)azetidin-2-one

4-(2-benzyltetrazol-5-ylmethyl)azetidin-2-one

RS-1-(3-chloro-4-hydroxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-one