(E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate
CAS No.:1373127-98-0
Molecular Formula:C₂₀H₁₅ClF₃NO₂S
Molecular Weight:425.859
Hs Code.:

Synonyms:(E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate

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Chemical Property of (E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate

Chemical Property:

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Technology Process of (E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate

There total 4 articles about (E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₃ClF₃NO₂S

: 1373127-98-0
(E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate

Guidance literature:: With sodium cyanoborohydride; In methanol; acetic acid; at 0 ℃; for 1.25h; Inert atmosphere;
DOI:10.1016/j.jorganchem.2012.02.009

Reference yield:

: 1373128-04-1
4-chlorophenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine

: 1373127-98-0
(E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis(benzonitrile)palladium(II) dichloride; p-benzoquinone; lithium chloride / tetrahydrofuran / 5 h / 70 °C / Inert atmosphere

2: sodium cyanoborohydride / methanol; acetic acid / 1.25 h / 0 °C / Inert atmosphere

With bis(benzonitrile)palladium(II) dichloride; sodium cyanoborohydride; p-benzoquinone; lithium chloride; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1016/j.jorganchem.2012.02.009

Reference yield:

: 144008-07-1
N-(p-chlorophenyl) trifluoroacetimidoyl iodide

: 1373127-98-0
(E)-methyl 3-(2-(1-(4-chlorophenylamino)-2,2,2-trifluoroethyl)benzo[b]thiophen-3-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 20 °C / Inert atmosphere

2: bis(benzonitrile)palladium(II) dichloride; p-benzoquinone; lithium chloride / tetrahydrofuran / 5 h / 70 °C / Inert atmosphere

3: sodium cyanoborohydride / methanol; acetic acid / 1.25 h / 0 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; sodium cyanoborohydride; triethylamine; p-benzoquinone; lithium chloride; In tetrahydrofuran; methanol; acetic acid; 1: Sonogashira coupling;
DOI:10.1016/j.jorganchem.2012.02.009