N-(tosyloxy)picolinimidoyl cyanide

Base Information

• Chemical Name: N-(tosyloxy)picolinimidoyl cyanide
• CAS No.: 121168-93-2
• Molecular Formula: C₁₄H₁₁N₃O₃S
• Molecular Weight: 301.326
• Mol file: 121168-93-2.mol

Synonyms:N-(tosyloxy)picolinimidoyl cyanide

Chemical Property of N-(tosyloxy)picolinimidoyl cyanide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tosyloxy)picolinimidoyl cyanide

There total 2 articles about N-(tosyloxy)picolinimidoyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.7%

(hydroxyimino)-2-pyridylacetonitrile (146561-41-3,4185-96-0) + p-toluenesulfonyl chloride (98-59-9) → N-(tosyloxy)picolinimidoyl cyanide (121168-93-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1248/cpb.c13-01005

Reference yield:

pyridine-2-acetonitrile (2739-97-1) → N-(tosyloxy)picolinimidoyl cyanide (121168-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; acetic acid

2: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

With acetic acid; triethylamine; sodium nitrite; In dichloromethane;

DOI:10.1248/cpb.c13-01005

upstream raw materials:

(hydroxyimino)-2-pyridylacetonitrile

p-toluenesulfonyl chloride

pyridine-2-acetonitrile