6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid

Base Information

Chemical Name:6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid
CAS No.:852700-65-3
Molecular Formula:C₃₈H₅₁NO₆Si
Molecular Weight:645.912
Hs Code.:

6-[(9<i>H</i>-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid

Synonyms:6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid

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Chemical Property of 6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid

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Technology Process of 6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid

There total 7 articles about 6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 852700-64-2
(6-hydroxy-hexyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

: 852700-65-3
6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/ol0502578

Reference yield:

: 6-{[1-(3-Methoxy-4-triisopropylsilanyloxy-phenyl)-meth-(E)-ylidene]-amino}-hexan-1-ol

: 852700-65-3
6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 4.31 g / NaBH₄ / methanol / 1 h / 20 °C

2: 81 percent / NaHCO₃ / H₂O; acetone / 20 h / 20 °C

3: 57 percent / RuCl₃*H₂O; NaIO₄ / CCl₄; acetonitrile; H₂O / 1 h / 20 °C

With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; sodium hydrogencarbonate; In methanol; tetrachloromethane; water; acetone; acetonitrile;
DOI:10.1021/ol0502578

Reference yield:

: 852700-63-1
6-(3-methoxy-4-triisopropylsilanyloxy-benzylamino)-hexan-1-ol

: 852700-65-3
6-[(9H-fluoren-9-ylmethoxycarbonyl)-(3-methoxy-4-triisopropylsilanyloxy-benzyl)-amino]-hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / NaHCO₃ / H₂O; acetone / 20 h / 20 °C

2: 57 percent / RuCl₃*H₂O; NaIO₄ / CCl₄; acetonitrile; H₂O / 1 h / 20 °C

With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate; In tetrachloromethane; water; acetone; acetonitrile;
DOI:10.1021/ol0502578