6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

Base Information

Chemical Name:6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline
CAS No.:1441146-93-5
Molecular Formula:C₂₃H₂₄ClFN₄O₄
Molecular Weight:474.919
Hs Code.:

Synonyms:6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

Suppliers and Price of 6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

There total 4 articles about 6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 612501-52-7
4-(3-chloro-2-fluoroanilino)-6-hydroxy-7-methoxyquinazoline

: 141699-55-0
tert-butyl 3-hydroxyazetidine-1-carboxylate

: 1441146-93-5
6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

Guidance literature:: tert-butyl 3-hydroxyazetidine-1-carboxylate; With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -20 ℃; for 0.25h; Inert atmosphere;

4-(3-chloro-2-fluoroanilino)-6-hydroxy-7-methoxyquinazoline; In tetrahydrofuran; at -20 - 70 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ml400146c

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1441146-93-5
6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 3 h / 80 °C / Inert atmosphere

2.1: ammonium hydroxide / methanol / 2 h / 50 °C / Inert atmosphere

3.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.25 h / -20 °C / Inert atmosphere

3.2: 24 h / -20 - 70 °C / Inert atmosphere

With ammonium hydroxide; di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; isopropyl alcohol;
DOI:10.1021/ml400146c

Reference yield:

: 612501-80-1
4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate monohydrochloride

: 1441146-93-5
6-{[(1-tert-butoxycarbonyl)azetidin-3-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium hydroxide / methanol / 2 h / 50 °C / Inert atmosphere

2.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.25 h / -20 °C / Inert atmosphere

2.2: 24 h / -20 - 70 °C / Inert atmosphere

With ammonium hydroxide; di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1021/ml400146c