3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591824-06-4
Molecular Formula:C₂₁H₁₅ClF₃N₅O₄
Molecular Weight:493.829
Hs Code.:

3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Synonyms:3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Technology Process of 3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 12 articles about 3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591827-35-8
3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591824-06-4
3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: In N,N-dimethyl-formamide;

Reference yield:

: 1591827-18-7
4-(tert-butoxymethyl)-6-chloro-3-methoxypyridazine

: 1591824-06-4
3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: methanol; ethyl acetate

2: sodium tetrahydroborate / tetrahydrofuran; methanol

3: dichloromethane

4: N,N-dimethyl-formamide; ethyl acetate

5: trifluoroacetic acid

6: dichloromethane

8: N,N-dimethyl-formamide

With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1591827-20-1
methyl 5-(tert-butoxymethyl)-6-methoxypyridazine-3-carboxylate

: 1591824-06-4
3-chloro-5-((1-((5-(cyclopropyl(hydroxy)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol

2: dichloromethane

3: N,N-dimethyl-formamide; ethyl acetate

4: trifluoroacetic acid

5: dichloromethane

7: N,N-dimethyl-formamide

With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;