(2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal

Base Information

Chemical Name:(2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal
CAS No.:284035-47-8
Molecular Formula:C₂₁H₃₆O₃Si
Molecular Weight:364.601
Hs Code.:

Synonyms:(2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal

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Chemical Property of (2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal

Chemical Property:

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Technology Process of (2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal

There total 4 articles about (2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 284035-45-6
(2R,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptan-1-ol

: 284035-47-8
(2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal

Guidance literature:: With pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1016/S0040-4039(00)00383-X

Reference yield:

: 78999-24-3
5-benzyloxy-1-pentanal

: 284035-47-8
(2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / Bu₂BOTf; Et₃N / CH₂Cl₂ / 3 h / -78 - 0 °C

2: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

3: 74 percent / NaBH₄ / tetrahydrofuran; H₂O / 48 h / 20 °C

4: 97 percent / SO₃*Py; Et₃N / dimethylsulfoxide / 1 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; pyridine-SO₃ complex; di-n-butylboryl trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1: aldol coupling / 2: Etherification / 3: Reduction / 4: Oxidation;
DOI:10.1016/S0040-4039(00)00383-X

Reference yield:

: 171189-79-0
(S)-4-Benzyl-3-((2S,3R)-7-benzyloxy-3-hydroxy-2-methyl-heptanoyl)-oxazolidin-2-one

: 284035-47-8
(2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

2: 74 percent / NaBH₄ / tetrahydrofuran; H₂O / 48 h / 20 °C

3: 97 percent / SO₃*Py; Et₃N / dimethylsulfoxide / 1 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; pyridine-SO₃ complex; triethylamine; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1: Etherification / 2: Reduction / 3: Oxidation;
DOI:10.1016/S0040-4039(00)00383-X