(2S,3R)-8-chloro-3-isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]benzothiazole

Base Information

Chemical Name:(2S,3R)-8-chloro-3-isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]benzothiazole
CAS No.:1266398-82-6
Molecular Formula:C₁₉H₁₉ClN₂S
Molecular Weight:342.892
Hs Code.:

Synonyms:(2S,3R)-8-chloro-3-isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]benzothiazole

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Chemical Property of (2S,3R)-8-chloro-3-isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]benzothiazole

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Technology Process of (2S,3R)-8-chloro-3-isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]benzothiazole

There total 2 articles about (2S,3R)-8-chloro-3-isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1266398-75-7
(2S)-2-((S)-((6-chlorobenzo[d]thiazol-2-yl)amino)(phenyl)methyl)-3-methylbutan-1-ol

: 1266398-82-6
(2S,3R)-8-chloro-3-isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]benzothiazole

Guidance literature:: (2S)-2-((S)-((6-chlorobenzo[d]thiazol-2-yl)amino)(phenyl)methyl)-3-methylbutan-1-ol; With thionyl chloride; In toluene; at 120 ℃;

With sodium hydroxide; In water;
DOI:10.1039/c0ob00515k

Reference yield:

: 3622-23-9
2,6-dichloro-1,3-benzothiazole

: 1203507-00-9
(S)-2-((S)-amino(phenyl)methyl)-3-methylbutan-1-ol hydrochloride

: 1266398-82-6
(2S,3R)-8-chloro-3-isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]benzothiazole

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 145 °C / Inert atmosphere; Microwave irradiation

2: thionyl chloride / toluene / 120 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile;
DOI:10.1039/c0ob00515k