2'-Deoxy-O⁶-<(p-nitrophenyl)ethyl>-N²,3',5'-triacetylguanosine

Base Information

• Chemical Name: 2'-Deoxy-O⁶-<(p-nitrophenyl)ethyl>-N²,3',5'-triacetylguanosine
• CAS No.: 132183-38-1
• Molecular Formula: C₂₄H₂₆N₆O₉
• Molecular Weight: 542.505
• Mol file: 132183-38-1.mol

Synonyms:2'-Deoxy-O⁶-<(p-nitrophenyl)ethyl>-N²,3',5'-triacetylguanosine

Chemical Property of 2'-Deoxy-O⁶-<(p-nitrophenyl)ethyl>-N²,3',5'-triacetylguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-Deoxy-O⁶-<(p-nitrophenyl)ethyl>-N²,3',5'-triacetylguanosine

There total 2 articles about 2'-Deoxy-O⁶-<(p-nitrophenyl)ethyl>-N²,3',5'-triacetylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4-nitrophenyl)ethanol (100-27-6) + 2-(acetylamino)-9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one (4318-05-2) → 2'-Deoxy-O6-<(p-nitrophenyl)ethyl>-N2,3',5'-triacetylguanosine (132183-38-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; for 2h; Ambient temperature;

DOI:10.1021/jo00122a048

Reference yield:

2'-deoxyguanosine (961-07-9) → 2'-Deoxy-O6-<(p-nitrophenyl)ethyl>-N2,3',5'-triacetylguanosine (132183-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / pyridine / 1.5 h / Heating

2: 100 percent / diethylazodicarboxylate, triphenylphosphine / dioxane / 2 h / Ambient temperature

With pyridine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane;

DOI:10.1021/jo00122a048

Reference yield: 87.0%

2'-Deoxy-O6-<(p-nitrophenyl)ethyl>-N2,3',5'-triacetylguanosine (132183-38-1) → 2'-deoxy-O6-<2-(4-nitrophenyl)ethyl>guanosine (86137-72-6)

Guidance literature:

With ammonia; for 144h;

DOI:10.1016/S0040-4039(00)97168-5

upstream raw materials:

2-(4-nitrophenyl)ethanol

2-(acetylamino)-9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one

2'-deoxyguanosine

Downstream raw materials:

2'-deoxy-O⁶-<2-(4-nitrophenyl)ethyl>guanosine

2-fluoro-O⁶-(2-(p-nitrophenyl)ethyl)-2'-deoxyinosine

2'-Deoxy-O⁶-<(p-nitrophenyl)ethyl>-N²-(1-pyrenylmethyl)guanosine

2'-Deoxy-5'-(p-dimethoxytrityl)-N²-(1-pyrenylmethyl)guanosine