4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide

Base Information

Chemical Name:4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide
CAS No.:1610518-53-0
Molecular Formula:C₂₃H₃₀N₄O₅S₂
Molecular Weight:506.647
Hs Code.:

Synonyms:4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide

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Chemical Property of 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide

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Technology Process of 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide

There total 5 articles about 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610518-53-0
4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

5.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; n-butyllithium; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water;

Reference yield:

: 98961-97-8
piperazine-1-sulfonic acid dimethylamide

: 1610520-45-0
7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 1610518-53-0
4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1610520-27-8
4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 1610518-53-0
4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-N,N-dimethylpiperazine-1-sulphonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

2.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

2.2: 20 °C

3.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

4.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water;