(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁ hydrochloride

Base Information

• Chemical Name: (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁ hydrochloride
• CAS No.: 1553977-61-9
• Molecular Formula: C₂₂H₂₂N₆O*ClH
• Molecular Weight: 423.909

Synonyms:(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁ hydrochloride

Chemical Property of (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁ hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁ hydrochloride

There total 5 articles about (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁ hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl-6-d1)-piperidine-1-carboxylate (1553977-58-4) → (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d1 hydrochloride (1553977-61-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 65h;

Reference yield:

3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d1 (1553977-51-7) → (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d1 hydrochloride (1553977-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate monohydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 30 h / Inert atmosphere; Reflux

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3: hydrogenchloride / 1,4-dioxane / 65 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate monohydrate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d1 (1553977-55-1) → (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d1 hydrochloride (1553977-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2: hydrogenchloride / 1,4-dioxane / 65 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane;

upstream raw materials:

1H-pyrazolo[3,4-d]pyrimidin-4-amine-3,6-d₂

3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁

(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl-6-d₁)-piperidine-1-carboxylate

Downstream raw materials:

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl-6-d₁)piperidin-1-yl)prop-2-en-2,3,3-d₃-1-one

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl-6-d₁)piperidin-1-yl)prop-2-en-1-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1553977-61-9 (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-6-d₁ hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send