carbonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester

Base Information

Chemical Name:carbonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester
CAS No.:339571-01-6
Molecular Formula:C₃₆H₄₁N₃O₉Si
Molecular Weight:687.822
Hs Code.:

carbonic acid 2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester

Synonyms:carbonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester

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Chemical Property of carbonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester

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Technology Process of carbonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester

There total 2 articles about carbonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101527-40-6
5'-O-tert-butyldiphenylsilylthymidine

: 179691-31-7
2-(2-nitrophenyl)propyl chloroformate

: Carbonic acid 1-{(2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-[2-(2-nitro-phenyl)-propoxycarbonyloxy]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl ester 2-(2-nitro-phenyl)-propyl ester

: 339571-01-6
carbonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 14h;
DOI:10.1021/ol0069150

Reference yield:

: 64987-77-5
2-(2-nitrophenyl)propanol

: 339571-01-6
carbonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(2-nitro-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; toluene / 0 - 20 °C

2: 3.8 g / pyridine / tetrahydrofuran / 14 h / 0 - 20 °C

With pyridine; In tetrahydrofuran; toluene;
DOI:10.1021/ol0069150