N-benzyloxy-N-{(2R)-cyclopentylmethyl-3-[2-(furan-2-carbonyl)-pyrazolidin-1-yl]-3-oxo-propyl}formamide

Base Information

• Chemical Name: N-benzyloxy-N-{(2R)-cyclopentylmethyl-3-[2-(furan-2-carbonyl)-pyrazolidin-1-yl]-3-oxo-propyl}formamide
• CAS No.: 706778-87-2
• Molecular Formula: C₂₅H₃₁N₃O₅
• Molecular Weight: 453.538
• Mol file: 706778-87-2.mol

Synonyms:N-benzyloxy-N-{(2R)-cyclopentylmethyl-3-[2-(furan-2-carbonyl)-pyrazolidin-1-yl]-3-oxo-propyl}formamide

Chemical Property of N-benzyloxy-N-{(2R)-cyclopentylmethyl-3-[2-(furan-2-carbonyl)-pyrazolidin-1-yl]-3-oxo-propyl}formamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxy-N-{(2R)-cyclopentylmethyl-3-[2-(furan-2-carbonyl)-pyrazolidin-1-yl]-3-oxo-propyl}formamide

There total 2 articles about N-benzyloxy-N-{(2R)-cyclopentylmethyl-3-[2-(furan-2-carbonyl)-pyrazolidin-1-yl]-3-oxo-propyl}formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-furancarbonyl chloride (527-69-5) + N-benzyloxy-N-[(2R)-cyclopentylmethyl-3-oxo-3-pyrazolidin-1-yl-propyl]formamide (706778-86-1) → N-benzyloxy-N-{(2R)-cyclopentylmethyl-3-[2-(furan-2-carbonyl)-pyrazolidin-1-yl]-3-oxo-propyl}formamide (706778-87-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

Reference yield:

2-[3-(benzyloxyformylamino)-(2R)-cyclopentylmethyl-propionyl]-pyrazolidine-1-carboxylic acid tert-butyl ester (706778-85-0) → N-benzyloxy-N-{(2R)-cyclopentylmethyl-3-[2-(furan-2-carbonyl)-pyrazolidin-1-yl]-3-oxo-propyl}formamide (706778-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate; acetic acid / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With boron trifluoride diethyl etherate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2011.04.132

upstream raw materials:

2-furancarbonyl chloride

N-benzyloxy-N-[(2R)-cyclopentylmethyl-3-oxo-3-pyrazolidin-1-yl-propyl]formamide

2-[3-(benzyloxyformylamino)-(2R)-cyclopentylmethyl-propionyl]-pyrazolidine-1-carboxylic acid tert-butyl ester