tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate

Base Information

• Chemical Name: tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate
• CAS No.: 1208241-39-7
• Molecular Formula: C₅₇H₄₄O₈
• Molecular Weight: 856.972
• Mol file: 1208241-39-7.mol

Synonyms:tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate

Chemical Property of tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate

There total 7 articles about tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tetrakis(4-bromophenyl)methane (105309-59-9) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate (1208241-39-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; In tetrahydrofuran; water; at 70 ℃; for 72h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201803201

Reference yield:

trityl chloride (76-83-5) → tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate (1208241-39-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 0.5 h / 190 °C

1.2: 0.5 h / Reflux

2.1: sulfuric acid; phosphoric acid; isopentyl nitrite

3.1: bromine

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / 3 h / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphoric acid; sulfuric acid; bromine; cesium fluoride; isopentyl nitrite; In 1,2-dimethoxyethane;

DOI:10.1002/anie.201307340

Reference yield:

Phenyl-trityl-amine (4471-22-1) → tetramethyl 4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylate (1208241-39-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; phosphoric acid; isopentyl nitrite

2: bromine

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / 3 h / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphoric acid; sulfuric acid; bromine; cesium fluoride; isopentyl nitrite; In 1,2-dimethoxyethane;

DOI:10.1002/anie.201307340

upstream raw materials:

trityl chloride

Phenyl-trityl-amine

tetrakis(4-bromophenyl)methane

4-methoxycarbonylphenylboronic acid

Downstream raw materials:

4’,4’’,4’’’,4’’’’-methanetetrayltetrabiphenyl-4-carboxylic acid