(2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

Base Information

Chemical Name:(2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate
CAS No.:122778-47-6
Molecular Formula:C₂₂H₃₅F₃O₄Si
Molecular Weight:448.598
Hs Code.:

Synonyms:(2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

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Technology Process of (2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

There total 8 articles about (2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 17257-71-5,20445-31-2,56135-03-6,81655-41-6
(S)-Mosher acid

: 122778-46-5
(S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-pentan-1-ol

: 122778-47-6
(2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 15h; Ambient temperature;

Reference yield:

: 616-62-6
n-propylmalonic acid

: 122778-47-6
(2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / acetonitrile; CH₂Cl₂ / -40 deg C, 6 h; room temperature, 10 h

2: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

3: 87 percent / 4-(N,N-dimethylamino)pyridine, triethylamine / CH₂Cl₂; dimethylformamide / 10 h / Ambient temperature

4: 85 percent / di-isobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / -20 °C

5: 92 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 15 h / Ambient temperature

With dmap; oxalyl dichloride; diisobutylaluminum hydride; tetrabutylammonium borohydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 122778-29-4,122778-30-7,123463-90-1
(1R,3R,4S)-8-phenyl-p-menthan-3-yl hydrogen propylmalonate

: 122778-47-6
(2S)-2-(dimethyl-t-butylsiloxymethyl)pentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-hydroxysuccinimide, dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine, 2.) sodium borohydride / 1.) THF, room temperature, 1 h, 2.) room temperature, 1 h

2: 54 percent / 4-(N,N-dimethylamino)pyridine, triethylamine / CH₂Cl₂; dimethylformamide / 10 h / Ambient temperature

3: 1.) di-isobutylaluminium hydride, 2.) dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / 1.) THF, hexane, -20 deg C, 1 h, 2.) CH₂Cl₂, room temperature, 15 h

With dmap; sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; diisobutylaluminum hydride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;