Technology Process of (2'S,3'R,4'S)-5',5'-diethyl 3',4'-dimethyl 1-benzyl-5,6-difluoro-2-oxospiro[indoline-3,2'-pyrrolidine]-3',4',5',5'-tetracarboxylate
There total 2 articles about (2'S,3'R,4'S)-5',5'-diethyl 3',4'-dimethyl 1-benzyl-5,6-difluoro-2-oxospiro[indoline-3,2'-pyrrolidine]-3',4',5',5'-tetracarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
aminomalonic acid diethyl ester; 1-benzyl-5,6-difluoroindoline-2,3-dione;
With
C42H28O9P2;
In
toluene;
for 0.25h;
Molecular sieve;
dimethyl cis-but-2-ene-1,4-dioate;
In
toluene;
at 20 ℃;
for 36h;
optical yield given as %ee;
enantioselective reaction;
Molecular sieve;
DOI:10.1002/chem.201200358
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; hexane; N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: benzyl halide / 0 - 20 °C
2.1: C42H28O9P2 / toluene / 0.25 h / Molecular sieve
2.2: 36 h / 20 °C / Molecular sieve
With
C42H28O9P2; sodium hydride;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201200358
