4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine

Base Information

Chemical Name:4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine
CAS No.:1242015-72-0
Molecular Formula:C₁₈H₁₅ClF₃N₃O
Molecular Weight:381.785
Hs Code.:

Synonyms:4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine

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Chemical Property of 4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine

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Technology Process of 4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine

There total 4 articles about 4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1193511-97-5
5-bromo-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole

: 151414-47-0
2,6-difluoro-4-methoxybenzenamine

: 1242015-72-0
4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine

Guidance literature:: With potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 22h; Inert atmosphere; Reflux;

Reference yield:

: 75279-56-0
2-(2-chloro-4-fluorophenyl)acetonitrile

: 1242015-72-0
4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / ethyl acetate; ethanol / 3 h / 70 - 78 °C

2: acetic acid / ethanol / Reflux

3: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice

4: potassium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 22 h / Inert atmosphere; Reflux

With tert.-butylnitrite; sodium ethanolate; potassium carbonate; acetic acid; copper(ll) bromide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; ethyl acetate; acetonitrile;

Reference yield:

: 1193511-96-4
4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine

: 1242015-72-0
4-(2-chloro-4-fluorophenyl)-N-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice

2: potassium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 22 h / Inert atmosphere; Reflux

With tert.-butylnitrite; potassium carbonate; copper(ll) bromide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; acetonitrile;