5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

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Chemical Name:5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid
CAS No.:869891-96-3
Molecular Formula:C₁₅H₉BrCl₂N₂O₂S
Molecular Weight:432.125
Hs Code.:

Synonyms:5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

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Chemical Property of 5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

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Technology Process of 5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

There total 5 articles about 5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1013649-25-6
5-(5-bromothiophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester

: 869891-96-3
5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: With methanol; potassium hydroxide; at 20 ℃; Reflux; Inert atmosphere;
DOI:10.1021/jm800066v

Reference yield: 95.0%

: 869891-96-3
5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:

Reference yield:

: C₁₀H₉O₄S^(1-)*Li⁽¹⁺⁾

: 869891-96-3
5-(5-bromothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 24 h / 20 °C / Inert atmosphere

1.2: 16 h / 120 °C / Inert atmosphere

2.1: N-Bromosuccinimide / acetonitrile / 16 h / 0 - 20 °C / Inert atmosphere

3.1: potassium hydroxide / methanol / 3 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; potassium hydroxide; In methanol; ethanol; acetonitrile;
DOI:10.1039/c4ra01212g