Asterric acid

Base Information

• Chemical Name: Asterric acid
• CAS No.: 577-64-0
• Molecular Formula: C17H16O8
• Molecular Weight: 348.309
• European Community (EC) Number: 804-200-6
• UNII: J3Q23XL4KN
• DSSTox Substance ID: DTXSID60206405
• Nikkaji Number: J11.544D
• Wikipedia: Asterric_acid
• Wikidata: Q15410258
• Metabolomics Workbench ID: 137207
• ChEMBL ID: CHEMBL469424
• Mol file: 577-64-0.mol

Synonyms:asterric acid

Chemical Property of Asterric acid

Chemical Property:

• Vapor Pressure: 2.86E-13mmHg at 25°C
• Melting Point: 208-214 °C
• Boiling Point: 557.6°Cat760mmHg
• PKA: 2.97±0.34(Predicted)
• Flash Point: 203.7°C
• PSA: 122.52000
• Density: 1.406g/cm³
• LogP: 2.69190
• Storage Temp.: ?20°C
• Solubility.: Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide
• XLogP3: 3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 348.08451746
• Heavy Atom Count: 25
• Complexity: 481

Purity/Quality:

98.5% ^*data from raw suppliers

Asterric Acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: N
• Statements: 50
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)OC2=C(C=C(C=C2OC)O)C(=O)OC)C(=O)O)O
• Uses: Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.

Technology Process of Asterric acid

There total 1 articles about Asterric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ asterric acid (577-64-0)

Guidance literature:

4-Hydroxy-2'-methoxy-6'-methoxycarbonyl-6-methyl-grisdien-(2',5')-dion-(3,4'), 65percentig. H2SO4;

DOI:10.1039/jr9600004838

Reference yield:

asterric acid (577-64-0) → 3,5,6'-trihydroxy-4'-methyl-2,2'-oxy-di-benzoic acid

Guidance literature:

With potassium hydroxide; at 250 ℃;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + asterric acid (577-64-0) → 6'-hydroxy-3,5-dimethoxy-4'-methyl-2,2'-oxy-di-benzoic acid dimethyl ester (98134-11-3)

Guidance literature:

With diethyl ether; ethanol;

Downstream raw materials:

6'-hydroxy-3,5-dimethoxy-4'-methyl-2,2'-oxy-di-benzoic acid dimethyl ester

5,6'-diacetoxy-3-methoxy-4'-methyl-2,2'-oxy-di-benzoic acid-1-methyl ester