Technology Process of 3-(3-fluorophenyl)-2-phenylquinoxaline-6-carboxylic acid
There total 8 articles about 3-(3-fluorophenyl)-2-phenylquinoxaline-6-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); water; tricyclohexylphosphine;
In
1,4-dioxane;
at 95 ℃;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / 3 h / 0 °C / Reflux
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
3: ammonium chloride; iron / methanol / 2 h / Reflux
4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 3 h / 20 °C
5: phosphorus pentachloride / acetonitrile / 5 h / Reflux
6: tricyclohexylphosphine; potassium phosphate; water; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 95 °C / Sealed tube
With
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; phosphorus pentachloride; water; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tricyclohexylphosphine;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
6: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
2: ammonium chloride; iron / methanol / 2 h / Reflux
3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 3 h / 20 °C
4: phosphorus pentachloride / acetonitrile / 5 h / Reflux
5: tricyclohexylphosphine; potassium phosphate; water; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 95 °C / Sealed tube
With
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); phosphorus pentachloride; water; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tricyclohexylphosphine;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
5: |Suzuki Coupling;
