(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine

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Chemical Name:(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine
CAS No.:1351339-10-0
Molecular Formula:C₂₅H₃₁F₂N₇O₂
Molecular Weight:499.564
Hs Code.:

Synonyms:(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine

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Chemical Property of (3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine

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Technology Process of (3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine

There total 5 articles about (3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351342-61-4
((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester

: 1351339-10-0
(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine

Guidance literature:: ((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With ammonium hydroxide; In methanol; dichloromethane;

Reference yield:

: 1245079-22-4
[(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351339-10-0
(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 36 h / 100 °C

2: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1351342-50-1
4-(2-chloropyrimidin-5-yloxymethyl)piperidine-1-carboxylic acid benzyl ester

: 1351339-10-0
(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 36 h / 100 °C

2: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;