3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester

Base Information

• Chemical Name: 3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester
• CAS No.: 800374-56-5
• Molecular Formula: C₁₁H₁₃ClO₄
• Molecular Weight: 244.675
• Mol file: 800374-56-5.mol

Synonyms:3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester

Chemical Property of 3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester

There total 2 articles about 3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-benzaldehyde (691012-74-5) → 3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester (800374-56-5)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 2 h / Heating

2: H₂ / Pd/C / ethyl acetate / 10 h

3: TBAF / tetrahydrofuran / 0.5 h

With tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene;

DOI:10.1055/s-2004-831314

Reference yield:

3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-propionic acid methyl ester → 3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester (800374-56-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;

DOI:10.1055/s-2004-831314

Reference yield: 55.0%

3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester (800374-56-5) + 2,2-Dimethyl-propionic acid (Z)-5-((2S,3S,7R)-2-ethynyl-7-hydroxy-1-oxa-spiro[2.4]hept-4-en-4-yl)-3-(4-methoxy-benzyloxymethyl)-pent-2-en-4-ynyl ester → 2,2-Dimethyl-propionic acid (Z)-5-((4R,5S)-5-{(R)-1-[2-chloro-6-methoxy-3-(2-methoxycarbonyl-ethyl)-phenoxy]-prop-2-ynyl}-4,5-dihydroxy-cyclopent-1-enyl)-3-(4-methoxy-benzyloxymethyl)-pent-2-en-4-ynyl ester (800374-64-5)

Guidance literature:

With cesium fluoride; In N,N-dimethyl-formamide; at 60 ℃; for 10h;

DOI:10.1055/s-2004-831314

upstream raw materials:

3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-benzaldehyde

Downstream raw materials:

2,2-Dimethyl-propionic acid (Z)-5-((4R,5S)-5-{(R)-1-[2-chloro-6-methoxy-3-(2-methoxycarbonyl-ethyl)-phenoxy]-prop-2-ynyl}-4,5-dihydroxy-cyclopent-1-enyl)-3-(4-methoxy-benzyloxymethyl)-pent-2-en-4-ynyl ester

C₃₅H₃₆ClNO₇

3-[2-Chloro-3-((R)-1-{(3aS,6aR)-4-[(Z)-5-hydroxy-3-(4-methoxy-benzyloxymethyl)-pent-3-en-1-ynyl]-2,2-dimethyl-6,6a-dihydro-cyclopenta[1,3]dioxol-3a-yl}-prop-2-ynyloxy)-4-methoxy-phenyl]-propionic acid methyl ester

3-[3-((R)-1-{(3aS,6aR)-4-[(Z)-5-Azido-3-(4-methoxy-benzyloxymethyl)-pent-3-en-1-ynyl]-2,2-dimethyl-6,6a-dihydro-cyclopenta[1,3]dioxol-3a-yl}-prop-2-ynyloxy)-2-chloro-4-methoxy-phenyl]-propionic acid methyl ester