ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Base Information

Chemical Name:ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate
CAS No.:1263940-48-2
Molecular Formula:C₂₆H₂₁F₃N₄O₂
Molecular Weight:478.474
Hs Code.:

Synonyms:ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

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Chemical Property of ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

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Technology Process of ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

There total 4 articles about ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6804-53-1
4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine

: 1264296-16-3
ethyl 2-benzyl-4-cyano-5-(dimethylamino)-2-methyl-3-oxopent-4-enoate

: 1263940-48-2
ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 120 ℃; for 16.25h; Irradiation with microwave;

Reference yield:

: 1264296-15-2
ethyl 2-benzyl-5-(hydroxyimino)-2-methyl-3-oxopentanoate

: 1263940-48-2
ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 16 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; ethanol / 16.25 h / 120 °C / Irradiation with microwave

With hydrogenchloride; In 1,4-dioxane; ethanol;

Reference yield:

: 107449-78-5
ethyl α-methyl-α-benzylacetoacetate

: 1263940-48-2
ethyl 2-(6-cyano-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 90 °C

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0 - 20 °C

3: 16 h / 20 °C

4: hydrogenchloride / 1,4-dioxane; ethanol / 16.25 h / 120 °C / Irradiation with microwave

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;