Technology Process of 2-hydroxy-4-(2-oxo-6-phenyl-5-(thiophen-3-yl)-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid
There total 6 articles about 2-hydroxy-4-(2-oxo-6-phenyl-5-(thiophen-3-yl)-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-phenyl-2-(thiophen-3-yl)ethan-1-one; 4-formyl-2-hydroxy-benzoic acid methyl ester; ammonium acetate;
With
cycl-isopropylidene malonate; acetic acid;
Reflux;
With
water; sodium hydroxide;
In
methanol;
at 40 ℃;
for 6h;
With
hydrogenchloride;
In
methanol; water;
at 20 ℃;
pH=5;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 °C
3.1: cycl-isopropylidene malonate; acetic acid / Reflux
3.2: 6 h / 40 °C
3.3: 20 °C / pH 5
With
cycl-isopropylidene malonate; n-butyllithium; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 80 °C / 3750.38 Torr
2.1: aluminum (III) chloride / dichloromethane / 0.05 h / Reflux
3.1: cycl-isopropylidene malonate; acetic acid / Reflux
3.2: 6 h / 40 °C
3.3: 20 °C / pH 5
With
aluminum (III) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; cycl-isopropylidene malonate; palladium diacetate; acetic acid; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;