phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate

Base Information

• Chemical Name: phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate
• CAS No.: 144876-63-1
• Molecular Formula: C₂₈H₃₀N₄O₃
• Molecular Weight: 470.571
• Mol file: 144876-63-1.mol

Synonyms:phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate

Chemical Property of phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate

There total 3 articles about phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

9H-fluoren-9-ylmethyl -3-(1H-indol-3-ylmethyl)-3-methyl-4,9-dioxo-7,11-diphenyl-10-oxa-2,5,8-triazaundecanoate (144876-58-4) → phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate (144876-63-1)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; at 0 ℃; for 17h;

DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

((S)-2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester (130406-36-9,142854-51-1) → phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate (144876-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / 1) THF, EtOAc, 25 deg C, 2 h, 2) 25 deg C, 17 h

2: 80 percent / piperidine / dimethylformamide / 17 h / 0 °C

With piperidine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

N-[(9H-fluoren-9-ylmethyloxy)-carbonyl]-α-methyl-DL-tryptophan (134558-28-4) → phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate (144876-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / 1) THF, EtOAc, 25 deg C, 2 h, 2) 25 deg C, 17 h

2: 80 percent / piperidine / dimethylformamide / 17 h / 0 °C

With piperidine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)86596-0

upstream raw materials:

9H-fluoren-9-ylmethyl -3-(1H-indol-3-ylmethyl)-3-methyl-4,9-dioxo-7,11-diphenyl-10-oxa-2,5,8-triazaundecanoate

((S)-2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester

N-[(9H-fluoren-9-ylmethyloxy)-carbonyl]-α-methyl-DL-tryptophan

Downstream raw materials:

<10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-10-methyl-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-pentaazaspiro<5,13>nonadecane-17-acetic acid

<10R-(10α,14α,17α)>-10-(1H-indol-3-ylmethyl)-10-methyl-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-pentaazaspiro<5,13>nonadecane-17-acetic acid

4-methyl-1-(phenylmethyl) -N-<<1-<<<<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(phenylmethoxy)carbonyl>amino>ethyl>amino>ethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate