1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane

Base Information

• Chemical Name: 1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane
• CAS No.: 86525-71-5
• Molecular Formula: C₁₁H₁₆O₃S
• Molecular Weight: 228.312
• Mol file: 86525-71-5.mol

Synonyms:1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane

Chemical Property of 1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane

There total 1 articles about 1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-bromo-2-methylthiophene (29421-92-9) + (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → 1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane (86525-71-5)

Guidance literature:

With sodium; potassium iodide; copper(II) oxide; at 90 ℃; for 36h;

Reference yield:

1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane (86525-71-5) → Toluene-4-sulfonic acid 1-hydroxymethyl-2-(5-methyl-thiophen-3-yloxy)-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 80percent AcOH / 0.5 h / 60 - 70 °C

2: pyridine / 24 h

With acetic acid; In pyridine;

Reference yield:

1-(5-methyl-3-thienyloxy)-2,3-O-isopropylidene propane (86525-71-5) → Toluene-4-sulfonic acid 2-hydroxy-3-(5-methyl-thiophen-3-yloxy)-propyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 80percent AcOH / 0.5 h / 60 - 70 °C

2: pyridine / 24 h

With acetic acid; In pyridine;

upstream raw materials:

4-bromo-2-methylthiophene

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

Downstream raw materials:

1-Isopropylamino-3-(5-methyl-thiophen-3-yloxy)-propan-2-ol

1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-(5-methyl-thiophen-3-yloxy)-propan-2-ol