Technology Process of [1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester
There total 9 articles about [1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
20percent Pd(OH)2/C;
In
ethanol;
at 20 ℃;
under 760.051 Torr;
DOI:10.1021/jm010531d
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 92 percent / Cs2CO3 / dimethylformamide / 18 h / 45 °C / Heating
2.1: Mg; iodomethane / diethyl ether / 1 h / Heating
2.2: 59 percent / diethyl ether / 1 h / 0 °C
3.1: 82 percent / LiAlH4 / tetrahydrofuran / 3 h
4.1: diphenylphosphoryl azide; DBU / toluene / 20 °C
5.1: LiAlH4 / tetrahydrofuran / 0 °C
6.1: PyBOP; DIEA / CH2Cl2
7.1: LiN(SiMe3)2 / tetrahydrofuran / 0 °C
8.1: H2 / 20percent Pd(OH)2/C / ethanol / 20 °C / 760.05 Torr
With
lithium aluminium tetrahydride; diphenylphosphoranyl azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; caesium carbonate; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; methyl iodide;
20percent Pd(OH)2/C;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm010531d
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82 percent / LiAlH4 / tetrahydrofuran / 3 h
2: diphenylphosphoryl azide; DBU / toluene / 20 °C
3: LiAlH4 / tetrahydrofuran / 0 °C
4: PyBOP; DIEA / CH2Cl2
5: LiN(SiMe3)2 / tetrahydrofuran / 0 °C
6: H2 / 20percent Pd(OH)2/C / ethanol / 20 °C / 760.05 Torr
With
lithium aluminium tetrahydride; diphenylphosphoranyl azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane;
20percent Pd(OH)2/C;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm010531d