[1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester
CAS No.:1025906-75-5
Molecular Formula:C₁₆H₂₁ClN₂O₄
Molecular Weight:340.807
Hs Code.:

[1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

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Chemical Property of [1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

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Technology Process of [1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

There total 9 articles about [1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [1-(3-benzyloxy-5-chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

: 1025906-75-5
[1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; 20percent Pd(OH)2/C; In ethanol; at 20 ℃; under 760.051 Torr;
DOI:10.1021/jm010531d

Reference yield:

: 591-35-5
3,5-dichlorophenol

: 1025906-75-5
[1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 92 percent / Cs₂CO₃ / dimethylformamide / 18 h / 45 °C / Heating

2.1: Mg; iodomethane / diethyl ether / 1 h / Heating

2.2: 59 percent / diethyl ether / 1 h / 0 °C

3.1: 82 percent / LiAlH₄ / tetrahydrofuran / 3 h

4.1: diphenylphosphoryl azide; DBU / toluene / 20 °C

5.1: LiAlH₄ / tetrahydrofuran / 0 °C

6.1: PyBOP; DIEA / CH₂Cl₂

7.1: LiN(SiMe₃)2 / tetrahydrofuran / 0 °C

8.1: H₂ / 20percent Pd(OH)2/C / ethanol / 20 °C / 760.05 Torr

With lithium aluminium tetrahydride; diphenylphosphoranyl azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; caesium carbonate; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; methyl iodide; 20percent Pd(OH)2/C; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm010531d

Reference yield:

: 53985-44-7
3-(benzyloxy)-5-chlorobenzoic acid

: 1025906-75-5
[1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / LiAlH₄ / tetrahydrofuran / 3 h

2: diphenylphosphoryl azide; DBU / toluene / 20 °C

3: LiAlH₄ / tetrahydrofuran / 0 °C

4: PyBOP; DIEA / CH₂Cl₂

5: LiN(SiMe₃)2 / tetrahydrofuran / 0 °C

6: H₂ / 20percent Pd(OH)2/C / ethanol / 20 °C / 760.05 Torr

With lithium aluminium tetrahydride; diphenylphosphoranyl azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; 20percent Pd(OH)2/C; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm010531d