(1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate

Base Information

Chemical Name:(1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate
CAS No.:956584-44-4
Molecular Formula:C₁₇H₂₀O₄
Molecular Weight:288.343
Hs Code.:

Synonyms:(1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate

Suppliers and Price of (1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate

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Technology Process of (1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate

There total 4 articles about (1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 107969-78-8
methyl benzylidenepyruvate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 956584-44-4
(1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate

Guidance literature:: cyclohexanone; With C₂₀H₃₇N₃S; benzoic acid; In water; at 20 ℃; for 0.166667h;

methyl benzylidenepyruvate; In water; for 12h; enantioselective reaction;
DOI:10.1002/cjoc.201400431

Reference yield: 50.0%

: 107969-78-8,6395-86-4
methyl 4-phenyl-2-oxo-3-butenoate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 956584-44-4
(1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate

Guidance literature:: With N-{(3aR,7aR)-octahydro-1,3-bis[(1R)-1-phenylethyl]-1H-1,3,2-benzodiazaphosphyl-2-oxide}-N'-[(2S)-2-pyrrolidinylmethyl]thiourea; benzoic acid; In water; at 25 ℃; for 48h; enantioselective reaction;
DOI:10.1002/ejoc.201801339

Reference yield:

: 107969-78-8
methyl benzylidenepyruvate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: C₁₇H₂₀O₄

: 956584-44-4
(1R,3S,5S,7S)-methyl-3-hydroxy-11-oxo-5-phenylbicyclo[5.3.1]undecane-3-carboxylate

Guidance literature:: With N-(((2S,4R)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide; 4-methoxybenzoic acid; at 20 ℃; for 48h; Title compound not separated from byproducts.;
DOI:10.1021/ol701669b