1-[(2-Bromophenyl)sulfonyl]-1H-pyrrole

Base Information

• Chemical Name: 1-[(2-Bromophenyl)sulfonyl]-1H-pyrrole
• CAS No.: 153624-58-9
• Molecular Formula: C₁₀H₈BrNO₂S
• Molecular Weight: 286.149
• DSSTox Substance ID: DTXSID301282822
• Mol file: 153624-58-9.mol

Synonyms:153624-58-9;SCHEMBL6771593;DTXSID301282822;KUC101218N;1-[(2-Bromophenyl)sulfonyl]-1H-pyrrole

Chemical Property of 1-[(2-Bromophenyl)sulfonyl]-1H-pyrrole

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 284.94591
• Heavy Atom Count: 15
• Complexity: 306

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)S(=O)(=O)N2C=CC=C2)Br

Technology Process of 1-[(2-Bromophenyl)sulfonyl]-1H-pyrrole

There total 2 articles about 1-[(2-Bromophenyl)sulfonyl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrole (139021-59-3) → 1-((2-bromophenyl)sulfonyl)-1H-pyrrole (153624-58-9)

Guidance literature:

With manganese(IV) oxide; In benzene; at 80 ℃; for 18h;

DOI:10.1016/j.tet.2016.03.088

Reference yield: 65.0%

pyrrole (109-97-7,30604-81-0) + o-bromobenzenesulfonyl chloride (2905-25-1) → 1-((2-bromophenyl)sulfonyl)-1H-pyrrole (153624-58-9)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jm970872k

Reference yield: 88.0%

1-((2-bromophenyl)sulfonyl)-1H-pyrrole (153624-58-9) → pyrrole (109-97-7,30604-81-0)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 1h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.1c03031

upstream raw materials:

pyrrole

o-bromobenzenesulfonyl chloride

1-(2-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrole

Downstream raw materials:

pyrrole