tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Base Information

Chemical Name:tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate
CAS No.:1572928-40-5
Molecular Formula:C₂₄H₂₈F₃N₅O₅S₂
Molecular Weight:587.644
Hs Code.:

Synonyms:tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

There total 20 articles about tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: C₁₄H₁₆F₃N₃OS

: 1572928-40-5
tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Temperature; Time; Inert atmosphere;

Reference yield:

: 1450620-13-9
benzyl (3S)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1572928-40-5
tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate; ruphos / 1,4-dioxane / 0.75 h / 75 °C / Inert atmosphere

2: trifluoroacetic acid; trifluorormethanesulfonic acid / 0.03 h / 20 °C

3: triethylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

With trifluorormethanesulfonic acid; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); triethylamine; trifluoroacetic acid; sodium t-butanolate; ruphos; In 1,4-dioxane; dichloromethane;

Reference yield:

: 4214-76-0,67476-67-9
5-nitro-pyridin-2-ylamine

: 1572928-40-5
tert-butyl (S-(((3S)-3-(1-propyn-1-yl)-4-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; dmap / dichloromethane / 18 h / 20 °C

2.1: ammonium chloride; zinc / tetrahydrofuran; methanol; water / 12 h / 20 °C

3.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 0.5 h / 0 - 10 °C

3.2: 0.75 h / 0 °C

4.1: triethylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; ammonium chloride; triethylamine; zinc; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;