(3S,4S)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate

Base Information

• Chemical Name: (3S,4S)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate
• CAS No.: 1245908-06-8
• Molecular Formula: C₂₂H₂₄BrNO₅
• Molecular Weight: 462.34
• Mol file: 1245908-06-8.mol

Synonyms:(3S,4S)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate

Chemical Property of (3S,4S)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4S)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate

There total 2 articles about (3S,4S)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-bromo-β-nitrostyrene (3156-37-4) + t-butyl 2-oxo-4-phenylbutanoate → (3S,4S)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate (1245908-06-8)

Guidance literature:

With (1S,1'S)-6,6'-dibromo-1,1'-biisoindoline; nickel(II) acetate tetrahydrate; triethylamine; at 20 ℃; for 16h; Reagent/catalyst; stereoselective reaction; Inert atmosphere;

DOI:10.1016/S1872-2067(14)60199-6

Reference yield:

(E)-1-bromo-4-(2-nitrovinyl)benzene (3156-37-4,5153-71-9) + t-butyl 2-oxo-4-phenylbutanoate → (3R,4R)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate + (3S,4S)-tert-butyl 3-benzyl-4-(4'-bromophenyl)-5-nitro-2-oxopentanoate (1245908-06-8)

Guidance literature:

With C₃₈H₆₂N₂*Cl^(1-)*Cu⁽²⁺⁾*HO^(1-); In isopropyl alcohol; at 20 ℃; for 8h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2010.04.009

upstream raw materials:

(E)-1-bromo-4-(2-nitrovinyl)benzene

4-bromo-β-nitrostyrene