N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride

Base Information

• Chemical Name: N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride
• CAS No.: 126485-80-1
• Molecular Formula: C₁₂H₁₇IN₂O₂*ClH
• Molecular Weight: 384.645
• Mol file: 126485-80-1.mol

Synonyms:N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride

Chemical Property of N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride

There total 4 articles about N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N-(2-Dimethylamino-ethyl)-2-(3-trimethylsilanyl-phenoxy)-acetamide (126485-68-5) → N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride (126485-80-1)

Guidance literature:

With hydrogenchloride; N-chloro-succinimide; sodium iodide; In acetic acid; at 65 ℃; for 1h;

DOI:10.1248/cpb.37.2276

Reference yield:

m-(Trimethylsilyl)phenol (17881-95-7) → N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride (126485-80-1)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOC₂H₅ / ethanol / 3 h / Heating

2: 2 N NaOH / 0.5 h

3: 71 percent / Phenyl N-phenylphosphoramidochloridate, triethylamine, / CH₂Cl₂ / Ambient temperature

4: 64 percent / 1.) N-chlorosuccinimid, NaI; 2.) HCl gas / acetic acid / 1 h / 65 °C

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; sodium ethanolate; triethylamine; Phenyl N-phenylphosphoramidochloridate; sodium iodide; In ethanol; dichloromethane; acetic acid;

DOI:10.1248/cpb.37.2276

Reference yield:

(3-Trimethylsilanyl-phenoxy)-acetic acid (126485-61-8) → N-(2-Dimethylamino-ethyl)-2-(3-iodo-phenoxy)-acetamide; hydrochloride (126485-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / Phenyl N-phenylphosphoramidochloridate, triethylamine, / CH₂Cl₂ / Ambient temperature

2: 64 percent / 1.) N-chlorosuccinimid, NaI; 2.) HCl gas / acetic acid / 1 h / 65 °C

With hydrogenchloride; N-chloro-succinimide; triethylamine; Phenyl N-phenylphosphoramidochloridate; sodium iodide; In dichloromethane; acetic acid;

DOI:10.1248/cpb.37.2276

upstream raw materials:

N-(2-Dimethylamino-ethyl)-2-(3-trimethylsilanyl-phenoxy)-acetamide

m-(Trimethylsilyl)phenol

(3-Trimethylsilanyl-phenoxy)-acetic acid