1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ⁴-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: 1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ⁴-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 221651-80-5
• Molecular Formula: C₁₉H₁₆Cl₃NO₃S
• Molecular Weight: 444.766
• Mol file: 221651-80-5.mol

Synonyms:1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ⁴-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property of 1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ⁴-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ⁴-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 1 articles about 1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ⁴-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,3-diphenyl-1,3-butadiene (2548-47-2) + N-Sulfinylcarbamidsaeure-2,2,2-trichlorethylester (33210-06-9) → 1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ4-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester (221651-80-5)

Guidance literature:

DOI:10.1016/S0040-4039(98)02663-X

Reference yield: 93.0%

1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ4-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester (221651-80-5) → 4,5-diphenyl-3,6-dihydro-2H-[1,2]thiazine 1-oxide (221651-81-6)

Guidance literature:

With zinc; In tert-butyl alcohol; Heating;

DOI:10.1016/S0040-4039(98)02663-X

Reference yield:

1-oxo-4,5-diphenyl-3,6-dihydro-1H-1λ4-[1,2]thiazine-2-carboxylic acid 2,2,2-trichloro-ethyl ester (221651-80-5) → 7-Methyl-3,4-diphenyl-5,8-dihydro-4aH-8a-thionia-1-aza-naphthalene; perchlorate

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / Zn / 2-methyl-propan-2-ol / Heating

2: 99 percent / (CF₃CO)2O / CH₂Cl₂ / -78 °C

3: 85 percent / SO₂Cl₂, 70 percent HClO₄ / diethyl ether

4: 2 percent / acetonitrile / Ambient temperature

With sulfuryl dichloride; perchloric acid; trifluoroacetic anhydride; zinc; In diethyl ether; dichloromethane; acetonitrile; tert-butyl alcohol;

DOI:10.1016/S0040-4039(98)02663-X

upstream raw materials:

2,3-diphenyl-1,3-butadiene

N-Sulfinylcarbamidsaeure-2,2,2-trichlorethylester

Downstream raw materials:

4,5-diphenyl-3,6-dihydro-2H-[1,2]thiazine 1-oxide

4,5-diphenyl-5H-1,2-thiazine