2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole

Base Information

Chemical Name:2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole
CAS No.:1607825-31-9
Molecular Formula:C₃₇H₅₇NO₄SiSn
Molecular Weight:726.659
Hs Code.:

Synonyms:2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole

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Chemical Property of 2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole

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Technology Process of 2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole

There total 5 articles about 2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1607825-30-8
2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)oxazole

: 1461-22-9
tributyltin chloride

: 1607825-31-9
2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole

Guidance literature:: 2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)oxazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

tributyltin chloride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.013

Reference yield:

: 56926-40-0
6-phenoxychroman-2-carboxylic acid

: 1607825-31-9
2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-methyl-morpholine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

3.3: -78 - 20 °C / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; borane-THF; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.03.013

Reference yield:

: 1607825-27-3
N-methoxy-N-methyl-6-phenoxychroman-2-carboxamide

: 1607825-31-9
2-(((tert-butyldimethylsilyl)oxy)(6-phenoxychroman-2-yl)methyl)-5-(tributylstannyl)oxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

2.3: -78 - 20 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; borane-THF; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.03.013