3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine

Base Information

Chemical Name:3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine
CAS No.:1425512-20-4
Molecular Formula:C₂₇H₂₀F₆N₂O₂
Molecular Weight:518.458
Hs Code.:

Synonyms:3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine

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Chemical Property of 3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine

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Technology Process of 3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine

There total 4 articles about 3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: C₉H₅ClF₆Zn

: 55826-72-7
3,4-bis(benzyloxy)-6-chloropyridazine

: 1425512-20-4
3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine

Guidance literature:: With palladium diacetate; XPhos; In tetrahydrofuran; at 65 ℃; for 16h; Inert atmosphere;

Reference yield: 33.0%

: 75462-59-8
3,5-bis(trifluoromethyl)benzyl chloride

: 55826-72-7
3,4-bis(benzyloxy)-6-chloropyridazine

: 1425512-20-4
3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine

Guidance literature:: 3,5-bis(trifluoromethyl)benzyl chloride; With palladium diacetate; magnesium; zinc(II) chloride; XPhos; In tetrahydrofuran; at 30 ℃; for 1h;

3,4-bis(benzyloxy)-6-chloropyridazine; In tetrahydrofuran; at 65 ℃; for 16h; Inert atmosphere;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1425512-20-4
3,4-bis(benzyloxy)-6-{[3,5-bis(trifluoromethyl)phenyl]-methyl}pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 17.17 h / 0 - 25 °C

2: palladium diacetate; XPhos / tetrahydrofuran / 16 h / 65 °C / Inert atmosphere

With palladium diacetate; sodium hydride; XPhos; In tetrahydrofuran; mineral oil;