methyl 2-(m-methylbenzylideneamino)acetate

Base Information

• Chemical Name: methyl 2-(m-methylbenzylideneamino)acetate
• CAS No.: 943759-24-8
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 943759-24-8.mol

Synonyms:methyl 2-(m-methylbenzylideneamino)acetate

Chemical Property of methyl 2-(m-methylbenzylideneamino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(m-methylbenzylideneamino)acetate

There total 1 articles about methyl 2-(m-methylbenzylideneamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + m-tolyl aldehyde (620-23-5) → methyl 2-(m-methylbenzylideneamino)acetate (943759-24-8)

Guidance literature:

glycine ethyl ester hydrochloride; With magnesium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

m-tolyl aldehyde; In dichloromethane; at 20 ℃;

DOI:10.1039/c1ob05291h

Reference yield: 97.0%

ethyl 2,3-diphenylcycloprop-2-enecarboxylate (7382-06-1) + methyl 2-(m-methylbenzylideneamino)acetate (943759-24-8) → 6-ethyl 2-methyl (1S,2S,4S,5R,6S)-1,5-diphenyl-4-(m-tolyl)-3-azabicyclo[3.1.0]hexane-2,6-dicarboxylate

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; (S,S_p)-R-Phosferrox; caesium carbonate; In tetrahydrofuran; at 0 ℃; stereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/acs.orglett.8b01686

Reference yield: 95.0%

methyl 2-(m-methylbenzylideneamino)acetate (943759-24-8) + N,N-diethyl-1-phenylcycloprop-2-ene-1-carboxamide → C25H30N2O3

Guidance literature:

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; In dichloromethane; at 20 ℃; for 34h; enantioselective reaction; Inert atmosphere;

upstream raw materials:

glycine ethyl ester hydrochloride

m-tolyl aldehyde

Downstream raw materials:

(2S,3S,5S)-4,4-di-tert-butyl 2-methyl 3-phenyl-5-m-tolylpyrrolidine-2,4,4-tricarboxylate

C₁₅H₁₉NO₄

(4R,6S,7R)-7-ethyl 4-methyl 6-m-tolyl-5-azaspiro[2.4]heptane-4,7-dicarboxylate

(2R,5R)-4,4-diethyl 2-methyl 3-(2,2-diphenylvinylidene)-5-m-tolylpyrrolidine-2,4,4-tricarboxylate