1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

Base Information

Chemical Name:1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine
CAS No.:1005196-33-7
Molecular Formula:C₂₀H₂₃ClFNSi₂
Molecular Weight:388.032
Hs Code.:

Synonyms:1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

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Chemical Property of 1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

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Technology Process of 1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

There total 1 articles about 1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1-(2-chloro-4-fluoro-6-iodo-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

: 536-74-3
phenylacetylene

: 1005196-33-7
1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

Guidance literature:: phenylacetylene; With TurboGrignard; In tetrahydrofuran; at 21 ℃; for 0.5h;

With zinc(II) chloride; In tetrahydrofuran; at -30 ℃; for 0.5h;

1-(2-chloro-4-fluoro-6-iodo-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 17h; Further stages.;
DOI:10.1021/ol7025872

Reference yield: 89.0%

: 1005196-33-7
1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

: 623-49-4
ethyl cyanoformate

: 1005196-39-3
2-chloro-6-fluoro-4-phenylethynyl-3-(2,2,5,5-tetramethyl-[1,2,5]azadisilolidin-1-yl)-benzoic acid ethyl ester

Guidance literature:: 1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine; With TMPMgCl*LiCl; In tetrahydrofuran; at 21 ℃; for 2h;

ethyl cyanoformate; In tetrahydrofuran; at -30 ℃; for 1.5h; Further stages.;
DOI:10.1021/ol7025872

Reference yield: 80.0%

: 1005196-33-7
1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

: 19158-51-1
P-toluenesulfonyl cyanide

: 2-chloro-6-fluoro-4-phenylethynyl-3-(2,2,5,5-tetramethyl-[1,2,5]azadisilolidin-1-yl)-benzonitrile

Guidance literature:: 1-(2-chloro-4-fluoro-6-phenylethynyl-phenyl)-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine; With TMPMgCl*LiCl; In tetrahydrofuran; at 21 ℃; for 2h;

P-toluenesulfonyl cyanide; In tetrahydrofuran; at -30 ℃; for 1.5h; Further stages.;
DOI:10.1021/ol7025872