(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one

Base Information

Chemical Name:(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one
CAS No.:83058-26-8
Molecular Formula:C₃₁H₅₂O₄Si
Molecular Weight:516.837
Hs Code.:

Synonyms:(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one

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Chemical Property of (1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one

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Technology Process of (1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one

There total 4 articles about (1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10385-30-5
4-(benzyloxy)butanoic acid

: 83058-26-8
(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / lithium diisopropylamide, hexamethylphosphoramide / tetrahydrofuran; hexane / 1.5 h / 0 deg C -> room temperature

2: 98 percent / lithium aluminium hydride / tetrahydrofuran / 0.75 h / 0 deg C -> room temperature

3: 87 percent / CrO₃*2C₅H₅N / CH₂Cl₂ / 0.25 h / 0 °C

4: CH₂Cl₂ / 17 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; dipyridine chromium trioxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00384a061

Reference yield:

: 83005-56-5
2-(2-Benzyloxy-ethyl)-4-methyl-pent-4-en-1-ol

: 83058-26-8
(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / CrO₃*2C₅H₅N / CH₂Cl₂ / 0.25 h / 0 °C

2: CH₂Cl₂ / 17 h / Ambient temperature

With dipyridine chromium trioxide; In dichloromethane;
DOI:10.1021/ja00384a061

Reference yield:

: 83005-55-4
2-(2-Benzyloxy-ethyl)-4-methyl-pent-4-enoic acid

: 83058-26-8
(1S,3R,4S,5R)-5-(2-Benzyloxy-ethyl)-1-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-4-hydroxy-3,7-dimethyl-oct-7-en-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / lithium aluminium hydride / tetrahydrofuran / 0.75 h / 0 deg C -> room temperature

2: 87 percent / CrO₃*2C₅H₅N / CH₂Cl₂ / 0.25 h / 0 °C

3: CH₂Cl₂ / 17 h / Ambient temperature

With lithium aluminium tetrahydride; dipyridine chromium trioxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00384a061