5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide

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Chemical Name:5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide
CAS No.:1442425-33-3
Molecular Formula:C₂₆H₃₆N₂O
Molecular Weight:392.585
Hs Code.:

Synonyms:5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide

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Chemical Property of 5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide

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Technology Process of 5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide

There total 5 articles about 5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1442432-72-5
5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

: 1442425-33-3
5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: 5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With ammonia; In tetrahydrofuran; for 0.0166667h;

Reference yield:

: 1442430-89-8
ethyl 1-(cyclohexylmethyl)-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate

: 1442425-33-3
5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 2.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / water; toluene / 3 h / 100 °C / Inert atmosphere

3.1: water; sodium hydroxide / methanol / 3 h / 70 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 0.02 h

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; palladium diacetate; caesium carbonate; N,N-dimethyl-formamide; sodium hydroxide; tricyclohexylphosphine; In 1,4-dioxane; methanol; dichloromethane; water; toluene;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1442425-33-3
5-(3-(tert-butyl)-5-cyclopropylphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 2.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / water; toluene / 3 h / 100 °C / Inert atmosphere

3.1: water; sodium hydroxide / methanol / 3 h / 70 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 0.02 h

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; palladium diacetate; caesium carbonate; N,N-dimethyl-formamide; sodium hydroxide; tricyclohexylphosphine; In 1,4-dioxane; methanol; dichloromethane; water; toluene;