6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol

Base Information

Chemical Name:6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol
CAS No.:141263-64-1
Molecular Formula:C₁₅H₂₀Cl₂O₂S
Molecular Weight:335.295
Hs Code.:

Synonyms:6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol

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Technology Process of 6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol

There total 7 articles about 6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

: 141263-63-0
1-Benzoylthio-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-2,4-hexanediol

: 141263-64-1
6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol

Guidance literature:: With sodium methylate; In tetrahydrofuran; methanol; for 2h; Heating;
DOI:10.1016/S0008-6215(00)90500-7

Reference yield:

: 101910-02-5,101910-03-6,141263-55-0
(3R,5R)-5-[2-(2,4-Dichloro-phenyl)-ethyl]-tetrahydro-furan-2,3-diol

: 141263-64-1
6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol

Guidance literature:: Multi-step reaction with 7 steps

1: 95.6 percent / NaBH₄ / ethanol / 1 h / 0 °C

2: 78.8 percent / pyridine / 3 h / Ambient temperature

3: 89.5 percent / p-toluenesulfonic acid, 2-methoxypropene / 0.67 h / 20 °C

4: 95 percent / Bu₄NF / tetrahydrofuran / 0.67 h / 20 °C

5: 81.8 percent / pyridine / 7 h / 20 °C

6: 86 percent / acetone / 11 h / Heating

7: 92.5 percent / 4.4M sodium methoxide / methanol; tetrahydrofuran / 2 h / Heating

With pyridine; sodium tetrahydroborate; 2-Methoxypropene; tetrabutyl ammonium fluoride; sodium methylate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1016/S0008-6215(00)90500-7

Reference yield:

: 141263-56-1
6-(2,4-Dichlorophenyl)-D-erythro-1,2,4-hexanetriol

: 141263-64-1
6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-1-mercapto-D-erythro-2,4-hexanediol

Guidance literature:: Multi-step reaction with 6 steps

1: 78.8 percent / pyridine / 3 h / Ambient temperature

2: 89.5 percent / p-toluenesulfonic acid, 2-methoxypropene / 0.67 h / 20 °C

3: 95 percent / Bu₄NF / tetrahydrofuran / 0.67 h / 20 °C

4: 81.8 percent / pyridine / 7 h / 20 °C

5: 86 percent / acetone / 11 h / Heating

6: 92.5 percent / 4.4M sodium methoxide / methanol; tetrahydrofuran / 2 h / Heating

With pyridine; 2-Methoxypropene; tetrabutyl ammonium fluoride; sodium methylate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; acetone;
DOI:10.1016/S0008-6215(00)90500-7