(((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid

Base Information

Chemical Name:(((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid
CAS No.:1429012-44-1
Molecular Formula:C₁₄H₁₅N₃O₆P₂S
Molecular Weight:415.303
Hs Code.:

Synonyms:(((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid

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Chemical Property of (((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid

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Technology Process of (((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid

There total 6 articles about (((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429012-43-0
tetraethyl (((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)bis(phosphonate)

: 1429012-44-1
(((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2013.02.006

Reference yield:

: C₁₅H₁₅N₃S

: 1429012-44-1
(((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: formamide / 48 h / 130 °C / Inert atmosphere

2: toluene / 48 h / 130 °C / Inert atmosphere; Sealed tube; Darkness

3: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With trimethylsilyl bromide; formamide; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.02.006

Reference yield:

: 1429012-12-3
N′-(3-cyano-5-(p-tolyl)-4-(trimethylsilyl)thiophen-2-yl)-N,N-dimethylformimidamide

: 1429012-44-1
(((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C

2: formamide / 48 h / 130 °C / Inert atmosphere

3: toluene / 48 h / 130 °C / Inert atmosphere; Sealed tube; Darkness

4: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With trimethylsilyl bromide; tetrabutyl ammonium fluoride; formamide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.02.006