1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Base Information

• Chemical Name: 1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
• CAS No.: 1401110-48-2
• Molecular Formula: C₃₁H₂₉IN₄O₆
• Molecular Weight: 680.499
• Mol file: 1401110-48-2.mol

Synonyms:1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Chemical Property of 1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

There total 3 articles about 1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(5-dimethoxytrityl-2-deoxy-β-D-ribofuranosyl)-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine (1401110-47-1) → 1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (1401110-48-2)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 40 - 55 ℃; for 3h;

Reference yield:

1-(2-deoxy-1-D-ribofuranosyl)-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine (216958-27-9) → 1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (1401110-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h

2: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 40 - 55 °C

With pyridine; water; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

C28H27IN4O5S (358979-27-8) → 1-(5-dimethoxytrityl-2-deoxy-3-D-ribofuranosyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (1401110-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 0.42 h

2: pyridine / 2 h

3: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 40 - 55 °C

With pyridine; methanol; water; sodium hydroxide; In tetrahydrofuran; methanol;

upstream raw materials:

1-(5-dimethoxytrityl-2-deoxy-β-D-ribofuranosyl)-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine

C₂₈H₂₇IN₄O₅S

1-(2-deoxy-1-D-ribofuranosyl)-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine

Downstream raw materials:

C₃₆H₃₂F₃N₅O₇

1-(5-dimethoxytrityl-2-deoxy-β-D-ribofuranosyl)-3-(4-acetoxybut-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

C₄₅H₄₉F₃N₇O₈P

1-(3-(2-cyanoethyl-N,N-diisopropyl)phosphoramidito-5-dimethoxytrityl-2-deoxy-β-D-ribofuranosyl)-3-(4-acetoxybut-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one